Changes in ethical, social, and political approach around cannabis and cannabinoids has given rise to a new appreciation of their potential. We know cannabidiol (CBD) for its medicinal benefits, particularly in the treatment of acne vulgaris. By using recent research, we will investigate fresh uses for CBD while highlighting its advantages.
Cannabidiol: anti-inflammatory effect
As recent research states, 35 out of 51 papers acknowledged that inflammation was a typical component of acne vulgaris and that it was important for the condition to get worse. Although not all of the chosen publications specifically addressed this element. One made reference to the fact that Cannabis sativa has been in use traditionally since 3000 BC to treat inflammatory diseases like arthritis and skin wounds coming from tissue edema.
Recent studies have examined the ability of CBD at a specific dose to reduce inflammation and treat mouth ulcers. They discovered that a dermal patch containing 0.1% CBD concentration dramatically reduced these lesions, demonstrating CBD’s anti-inflammatory effects. Others have shown that CBD reduces inflammation via influencing the immune system. Inflammation is decreased by CBD’s interaction with cannabinoid receptors in skin cells.
According to physicochemical studies, CBD acts on receptors like CB1, CB2, G protein-coupled receptor 55 (GPR55), transient receptor potential vanilloid (TRPV) channels, and peroxisome proliferator-activated receptors (PPARs) to decrease the production of proinflammatory molecules like cytokines and chemokines. Preclinical studies on murine models of multiple sclerosis and arthritis supported these results.
CBD: antimicrobial activity
The symptoms of acne vulgaris are significantly aggravated by skin-surface microorganisms. Improvement in symptoms may result from effective management of these microorganisms. According to the study, Staphylococcus and Streptococcus are the most prevalent bacteria on the skin, although Corynebacterium and Propionibacterium are also found there. Due to its role in the pathogenesis of acne, Cutibacterium acnes (formerly known as Propionibacterium acnes) is particularly relevant.
According to studies, CBD may be able to regulate sebum production in sebaceous glands, which would prevent acne from developing. In acne models treated with CBD, it has also been seen to lessen the proliferation of inflammatory cells. Additionally, CBD shows potential against bacterial biofilms that cause acne, making it a powerful bacteriostatic and bactericidal agent.
Research demonstrated CBD’s antibacterial effects on Gram-positive bacteria, including Staphylococcus aureus. CBD has the ability to damage the phospholipids in the cell membrane, increasing permeability and causing the release of essential intracellular components. Additionally, it inhibits protein synthesis and bacterial growth by entering bacterial cell membranes and attaching to ribosome units.
CBD vs acne – conclusions
The literature supports antibacterial and anti-inflammatory benefits of CBD in the treatment of acne vulgaris. Although we could see this subject in a number of articles, there is a need for an additional research to determine the specific impact of cannabidiol on the pathogenesis of acne vulgaris. Firstly, research should concentrate on clarifying mechanisms of action. Then, they should be evaluating effectiveness against various bacterial strains. And finally, research should be taking into account actual clinical situations. Future research will provide us a more solid scientific foundation and a clearer idea of how CBD can treat acne vulgaris.
Recent research has demonstrated that CBD possesses anti-inflammatory characteristics, which are crucial for the treatment of acne vulgaris. CBD’s ability to influence the immune system and interact with cannabinoid receptors on skin cells can decrease the nflammation. Additionally, CBD reduces sebum production in sebaceous glands, a factor in acne development. What is more, in acne models treated with CBD, a reduction in the proliferation of inflammatory cells has been noted. These results point to CBD as a potential therapeutic therapy for acne vulgaris.
It is feasible to build formulations with CBD as an active ingredient for the creation of a topical CBD-based medicine. For topical CBD delivery, the researches include many pharmacological formulations including gels, creams, and ointments. However, it is important to note that research on the usefulness and safety of topical cannabidiol in the treatment of acne vulgaris is still in its early stages. Thus, we need further clinical research and reviews to firmly establish its efficacy.